The tumor virus landscape of AIDS-related lymphomas

The tumor virus landscape of AIDS-related lymphomas.

Immunodeficiency dramatically increases susceptibility to cancer as a result of reduced immune surveillance and enhanced opportunities for virus-mediated oncogenesis. Although AIDS-related lymphomas (ARLs) are frequently associated with known oncogenic viruses, many cases contain no known transforming virus. To discover novel transforming viruses, we profiled a set of ARL samples using whole tr...

e-Blood LYMPHOID NEOPLASIA The tumor virus landscape of AIDS-related lymphomas

Department of Immunology and Microbial Pathogenesis, Memorial Sloan-Kettering Cancer Center, New York, NY; Cancer Program, Broad Institute of MIT and Harvard, Cambridge, MA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY; Department of Human Pathology and Oncology, University ...

AIDS-related lymphomas in Nigeria.

Aggressive non-Hodgkin's lymphoma (NHL), including primary central nervous system (CNS) lymphoma, lymphoblastic lymphoma and non-endemic Burkitt's lymphoma have been recognized as AIDS-defining cancers in most developed countries. However, HIV/AIDS epidemics appear not to have been associated with higher incidence of lymphomas in Africa. We therefore carried out this study to highlight the sign...

AIDS-related lymphomas: the Rhode Island experience.

Epidemiology and pathogenesis of AIDS-related lymphomas.

Among patients with congenital and acquired immunodeficiencies, non-Hodgkin's lymphoma (NHLs ) are the most common tumors of the immune system. In the setting of human immunodeficiency virus (HIV) infection, as many as 10% to 20% of people ultimately developed NHLs. These tumors are clinically aggressive, frequently involve extranodal sites, and often exhibit unique features that distinguish th...